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Top similar games like Genome Guardian

Genome Guardian: Dive into a Microscopic Mayhem

Genome Guardian isn’t your average shooter. This isn’t just blasting aliens; it’s a vibrant, bioluminescent battle against unspeakable microscopic horrors! Prepare for a deeply complex, yet surprisingly accessible, experience that will keep you hooked for hours.

Imagine a microscopic world teeming with bizarre creatures, each a potential threat. Your arsenal? Genetically engineered bioweapons! Combine DNA nucleotides – Adenine (rapid fire), Cytosine (precision), Guanine (spread), and Thymine (explosive) – to create devastating hybrid weapons. Think Bomb + Shotgun equals the Blast Shotgun, or double down on explosives for the Bazooka! Experimentation is key to unlocking the ultimate weapon, the Flak Cannon.

But the weaponry is just the beginning. Master 49 unique turrets, strategically placed to bolster your defenses. Mix and match 96 perks to radically alter your playstyle. Customize your loadout further with 75 weapon and turret mods, transforming your shots into anything from sticky laser mines to bouncing fireballs.

Each 20-minute run throws you into a chaotic dance of survival across 6 modes and multiple depths, constantly evolving thanks to 64 mutations that alter the challenges. Continue the fight endlessly, refining your strategy with permanent upgrades researched between runs. And did we mention the 75 bass-heavy electronic tunes that perfectly capture the intensity?

Genome Guardian is a masterpiece of accessibility too, boasting settings for colorblindness, motion sickness, and even arachnophobia! With 100 Steam achievements, trading cards, cloud saves, and Steam Deck compatibility, this microscopic adventure is ready to infect your gaming library.

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You’ve come to the right place! Our website is dedicated to helping gamers find the best games that are similar to their favorite titles. In this list, you will find games similar to Genome Guardian. The games are sorted by their release date, with the newer ones listed first.

NIMRODS: GunCraft Survivor

85%

Steam score

2024

Release year

Fiveamp

Developer

Tired of run-of-the-mill roguelites? In Nimrods: GunCraft Survivor, you’re a disposable clone testing ludicrous alien weaponry. Craft insane guns, deploy past creations as drones, and bio-engineer your successors. Explore bizarre biomes, conquer relentless aliens, and leave behind a legacy of overpowered, physics-defying firearms. Survival? Optional. Gun-crafting glory? Guaranteed.

[REDACTED]

89%

Steam score

2024

Release year

KRAFTON, Inc.

Developer

Escape Jupiter’s icy moon prison, Callisto, in [REDACTED]! Fight hordes of infected inmates and rival survivors in this roguelike shooter. Death is a learning experience; upgrade your arsenal and skills with each run. Conquer your reanimated corpse for powerful rewards. Risk it all for ultimate victory – or lose everything. Experience fast-paced action with a unique graphic novel style and punk soundtrack.

Voids Vigil

96%

Steam score

2024

Release year

caiys

Developer

Dive into Voids Vigil, a frantic auto-battler arena shooter! Blast robotic hordes, upgrade your arsenal of crazy weapons and drones, and master dashing maneuvers. Randomly generated levels and diverse character classes ensure endless replayability. Conquer The Void and claim the top spot on the Steam leaderboards!

Snezhinka:Sentinel Girls2

97%

Steam score

2024

Release year

hinyari9

Developer

In *Snezhinka: Sentinel Girls 2*, you’re a budget-conscious mercenary battling mechs to rescue your sister. This 2.5D shooter blends fast-paced action with strategic card upgrades, offering a compelling story, challenging modes, and online leaderboards. Will your meager salary be enough to save your family?

Etaine: Magic Survivor / 伊泰恩:魔法幸存者

93%

Steam score

2024

Release year

TEMagicGames

Developer

Etaine: Magic Survivor is a thrilling roguelike where you unleash devastating magic. Master 120 spells across 8 elements, equip 78 powerful artifacts, and unlock 151 talents for godlike power. Conquer 20 difficulty levels across 3 maps, achieving 100,000+ kills isn’t just possible, it’s encouraged! Strategic mana management and build crafting are key to survival. No plot, just pure, magical mayhem.

In Woods

88%

Steam score

2024

Release year

Vision Party

Developer

Survive the unforgiving forest in *In Woods*, a roguelike where monster battles, crafting, and strategic power-ups are key. Level up your character, craft items from woodland resources, and ultimately conquer a fearsome final boss. Each playthrough is a unique struggle for survival – how long will you last?

Pape Rangers

76%

Steam score

2024

Release year

OKJOY

Developer

Burn rubber in Pape Rangers! This bullet-hell roguelike delivers intense 20-30 minute combat sessions. Mix 10 characters with 7 weapons for endless build possibilities, mastering magic swords or gunnery. Adjustable difficulty and unique monsters ensure thrilling, cathartic gameplay – perfect for quick escapes from reality! Join the Discord for more!

Cat Bait

97%

Steam score

2024

Release year

Mayni prod.

Developer

Cat Bait: Cute pixel cats battle hordes of mice! Upgrade your feline squad, unlock unique abilities & skins, and conquer epic bosses in this addictive Vampire Survivors-style roguelite. Short, sweet sessions deliver endless replayability. Are you ready to become a cat hero?

Time Treker

77%

Steam score

2024

Release year

Leyo Games, 2P Games

Developer

Time Treker plunges you into a desperate fight to save Earth from alien bugs! Pilot powerful mechs, customizing them with diverse weapons and upgrades. Choose from three unique pilots and archetypes, mastering each to conquer challenging missions across multiple timelines. Will you succeed in rewriting history?

Astro Looter: Survivor

78%

Steam score

2024

Release year

Soda Game Studio

Developer

Astro Looter: Survivor blasts onto the scene! This unique 3D roguelike blends survival, tower defense, and mining in a challenging alien landscape. Command armored heroes, deploy orbital strikes, and upgrade your arsenal to survive waves of bugs. Rarely seen gameplay makes this a must-try for action roguelike and tower defense fans! Dare to conquer?

Pizza Hero

89%

Steam score

2024

Release year

Astro Hound

Developer

Slice through hordes of enemies as a pizza-shaped hero in Pizza Hero! This roguelite shoot ’em up lets you customize your pie with power-up toppings – pepperoni grenades, anyone? Random levels and endless gameplay guarantee replayability. Just watch out for flashing lights!